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The aim of the project is to develop protein-DNA hybrid switches, consisting of monoclonal antibodies and dsDNA-tethers that undergo large conformational changes. The main task will be to develop bioconjugation strategies to efficiently functionalize monoclonal antibodies with DNA and consequently construct DNA nanoswitches. I will study the effect of linker length and binders’ affinities on switching mechanism using BRET, SPR and Tethered Particle Motion (TPM).
I was born and raised in a capital of Poland – Warsaw and I moved to Cracow for my studies. During that time, I loved to travel and discover new places, I visited over 20 countries.
I started my studies with an idea that I want to become an anthropologist and study ancient mummies. However, I quickly fall in love with synthetic biology. I obtain my Bachelor degree in biotechnology and Masters degree in molecular biotechnology (Master project at the Department of Biophysics) at Jagiellonian University in Cracow. During my Master, I also worked in a local biotechnology Centre where I was involved in a project bridging GUV-based synthetic cells and DNA-origami. After graduation, I worked in a company, where I was producing and crystallizing recombinant proteins.
